Neuroglobin and cytoglobin: Two new entries in the hemoglobin superfamily

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Neuroglobin and cytoglobin: two new members of globin family

The globin family has long been defined by myoglobin and hemoglobin, proteins with the functions of oxygen storage and transportation, respectively. Recently, two new members of this family were discovered: neuroglobin present in neurons and retinal cells and cytoglobin found in various types of tissue. The increased expression of these proteins in hypoxic conditions first suggested a role in o...

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Neuroglobin and cytoglobin

Department of Physics–INFM and Center for Excellence in Biomedical Research, University of Genova, Via Dodecaneso 33, I-16146 Genova, 1Department of Biology, University ‘Roma Tre’, Viale Guglielmo Marconi 446, I-00146 Roma, Italy, 2Department of Biochemistry, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium, 3Institute of Molecular Genetics, Johannes Gutenberg University of ...

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Divergent distribution of cytoglobin and neuroglobin in the murine eye.

Neuroglobin (Ngb) and cytoglobin (Cygb) are two vertebrate globins with yet poorly defined functions. Previous studies had demonstrated a high expression level of neuroglobin in the mammalian retina, being in line with a respiratory function. Here we show that in the mouse eye, cytoglobin is localised in fibroblasts of the ciliary processes and the choroidea. In the neuronal retina, cytoglobin ...

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Neuroglobin and cytoglobin: oxygen-binding proteins in retinal neurons.

PURPOSE The goal of this study was to describe the detailed localization of the novel oxygen-binding molecules, neuroglobin (Ngb) and cytoglobin (Cygb), in mammalian retinas and to determine whether Ngb and Cygb are neuronal or glial proteins in the retina. METHODS Antibodies directed against Ngb and Cygb were used to examine their patterns of distribution in normal canine retinas. Immunoblot...

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ژورنال

عنوان ژورنال: Biochemistry and Molecular Biology Education

سال: 2004

ISSN: 1470-8175,1539-3429

DOI: 10.1002/bmb.2004.494032050386